منابع مشابه
Structural basis for receptor specificity of influenza B virus hemagglutinin.
Receptor-binding specificity of HA, the major surface glycoprotein of influenza virus, primarily determines the host ranges that the virus can infect. Influenza type B virus almost exclusively infects humans and contributes to the annual "flu" sickness. Here we report the structures of influenza B virus HA in complex with human and avian receptor analogs, respectively. These structures provide ...
متن کاملSubstrate Specificity of Neurotropic Influenza Virus Neuraminidases.
FIG. 1. Effect of incr-easing substrate concentrations upon the magnitude of reaction with three influenza virus enzymes. Substrate in 0.5 si phosphate-buffered saline (PBS), pH 6 as indicated, and PBS to a total of 0.25 ml (human ac-GP, 4 mg/ ml; ovo, 40 mg/nil; PSM, 30 mg/ml), 0.05 ml of enzyme. Enzymes for these studies were virus concentrates prepared from infected chorioallantoic fluid by ...
متن کاملGlycan Receptor for Influenza Virus
Influenza viruses are found in wide range of animals, including humans, in nature. When avian and human viruses simultaneously infect an intermediate host, such as pigs, genetic recombination can occur between these viruses. There is concern regarding interspecies transmission, both initial animal-to-animal infection and outbreaks of pandemic viruses in the human population. Hemagglutinin (HA) ...
متن کاملH9N2 influenza A viruses from poultry in Asia have human virus-like receptor specificity.
H9N2 influenza A viruses are currently widespread in chickens, quail, and other poultry in Asia and have caused a few cases of influenza in humans. In this study, we found that H9N2 viruses from Hong Kong live bird markets have receptor specificity similar to that of human H3N2 viruses. In addition, the neuraminidase of poultry H9N2 viruses has mutations in its hemadsorbing site, a characterist...
متن کاملContemporary North American influenza H7 viruses possess human receptor specificity: Implications for virus transmissibility.
Avian H7 influenza viruses from both the Eurasian and North American lineage have caused outbreaks in poultry since 2002, with confirmed human infection occurring during outbreaks in The Netherlands, British Columbia, and the United Kingdom. The majority of H7 infections have resulted in self-limiting conjunctivitis, whereas probable human-to-human transmission has been rare. Here, we used glyc...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2010
ISSN: 0002-9440
DOI: 10.2353/ajpath.2010.100066